Everyone knows you need to brush and floss daily. But what is the best toothpaste to brush with? That depends a lot on what you want in the flavor, fluoride, sensitivity and natural ingredients departments. Regardless of your previously established notions about what the best toothpaste is, there are quite a few options you won’t find at the local big box store for one reason or another. Here are the 8 best toothpastes you won’t find at the grocery store.

Euthymol-Toothpaste

Euthymol Toothpaste

With an attractive, art nouveau style design that hasn’t been updated in decades, Euthymol Toothpaste is an old-school style teeth cleaning product made with a blend of antiseptic ingredients and essential flavor oils. The paste itself has a bright pink color and a medicinal taste best described as “reminiscent of Pepto Bismol,” but we’re willing to cope with both of those things because of the prevention of mouth ulcers, the effectiveness of the toothpaste and the strong antiseptic properties of the product.

$6
Ajona-Stomatikum-Toothpaste

Ajona Stomatikum Toothpaste

Ajona toothpaste is made in Germany, only comes in a 25ml tube and is highly effective at making your whole mouth feel clean. The specially concentrated formula means that the tiny, travel tube will go a long way when it comes to brushing, and the fluoride-free formula means you won’t have to worry about allergies or inflammations. The toothpaste might have an indecipherable list of ingredients and a slight, but delicious, hint of licorice, but it’s one of our favorite toothpastes for travel.

$7
Toms-of-Maine-Whole-Care-Fluoride-Toothpaste

Tom's of Maine Whole Care Fluoride Toothpaste

Tom’s of Maine is an international, natural-ingredients-only brand that’s been running strong for over a decade. Tom’s of Maine might be owned by one of the huge C-name conglomerates that makes toothpaste, but that doesn’t stop their product from excelling when it comes to whitening, cavity-fighting, breath-freshening and tartar / plaque prevention. The natural, sustainable and responsible product is sourced in nature, made with simple and understandable ingredients, and built to be free of all artificial nonsense. If you want to clean your pearly whites with natural ingredients, this is the best toothpaste to use.

$8
Uncle-Harrys-Alkalizing-Toothpaste

Uncle Harry's Alkalizing Toothpaste

In order to use Uncle Harry’s Toothpaste you need to throw everything you think you know about toothpaste out the window. It doesn’t come out of a tube. It requires you to dip your toothbrush in a jar. It’s made with mineral clay, sea salt and pure plant essences. Uncle Harry’s is definitely a toothpaste that requires some getting used to, but the alkalizing paste has everything you need to keep your teeth clean, twice a day, for around a quarter of a year. Multiple users even claim that this alkalizing toothpaste reverses existing damage done to teeth.

$9
Twin-Lotus-Active-Charcoal

Twin Lotus Active Charcoal Toothpaste

Activated charcoal can be used for everything from treating alcohol poisoning and preventing hangovers to mold cleansing and water filtration, but we like to think it works best as a component of toothpaste. Twin Lotus Active Charcoal Toothpaste takes all those cleansing, anti-aging and preventative aspects of activated charcoal and works them in to a toothpaste that is healthy, eco-friendly, and innovative. Sure, it’s slightly gritty and has a mild bitter taste, but it also happens to be extremely effective when it comes to cleaning, whitening and preventing bad breath.

$10
Marvis-Jasmin-Mint

Marvis Jasmin Mint Toothpaste

This originally Italian toothpaste is packed with mint, tartar and irritation fighting ingredients and a gentle xylitol and sorbitan based formula to cleanse and condition your teeth and gums. This particular version is also packed with the subtle floral charm of jasmin that, quite literally, makes it feel kind of like a flower is blooming in your mouth. All Marvis toothpaste works and feels a little bit different than the big box brands you’re used to, but with the added floral notes we feel like this is one of the best toothpastes on the market.

$11
CloSYS-Fluoride-Toothpaste

CloSYS Fluoride Toothpaste

CloSYS Anticavity Flouride Toothpaste has all the features you’d expect from a great toothpaste. Freshens breath. Sulfate-free. Non-irritating. Anticavity. Low abrasion. pH balanced. No sodium lauryl sulfate. CloSYS has just the right amount of mint, won’t foam and will eliminate bad breath for hours—without irritating your gums or dental work.

$11
Supersmile-Professional-Whitening-System

Supersmile Professional Whitening System Toothpaste and Accelerator

Yes, this toothpaste “system” is expensive. Yes, you have to deal with both a toothpaste and accelerator every time you brush. Yes, this has been on TV. But Supersmile also happens to be one of the most effective teeth whitening toothpaste setups on the market, which is why it comes highly recommended from cosmetic dentists all over the US. Supersmile gets bonus points because it also works with sensitive teeth, which is something we can’t say for other whitening setups on the market.

$28